Clinical Research Methods and Biostatistics

Assignment Task

Your report should include (for each section) – 500 words equivalent

a) Produce at least one graph that appropriately displays the data. The graph should be the most appropriate for the data you are analysing. It could be a histogram, box plot, bar chart, scatter plot etc.

b) Identify an appropriate statistical test and explain.

c) Present the results and statistical analysis and briefly evaluate the outcome in a concluding paragraph Any supplementary information can be placed in clearly labelled Appendice.

Project: Clinical validation of serum IL-8 in colorectal cancer patients and efficacy of CETUX adjuvant treatment (Kanakis & Jones, 2021). Colorectal cancer (CRC) is the third most common cancer and mainly affects the gastrointestinal track with smoking as a risk factor. The clinical diagnosis of this type of malignancy relies on colonoscopy but often imaging techniques, such as CT and MRI, can be applied. Carcinoembryonic Antigen (CEA) has been used as a serum tumour marker for the diagnosis of CRC, showing a sensitivity of 17.4 % to 100 % and specificity ranging from 66.1 % to 98.4 % (Sørensen et al., 2016) which underlies that in some cases it is not a reliable diagnostic biomarker. In the recent years, there is an effort of developing interleukin 8 (IL-8) as a valuable serum biomarker for the early detection of CRC (Lee et al., 2012). Construct one summative table to describe the data (mean ± SE), identify any significant differences between controls and patients and describe any significant correlations between these biomarkers.

 

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Clinical Research Methods and Biostatistics
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